Protein Details: Voltage-gated sodium channel subunit beta-2
Protein ID
ICDB_Pro_0618
Protein Name
Voltage-gated sodium channel subunit beta-2
Gene Name
Scn2b
Organism
Rattus norvegicus (Rat)
Length
215 amino acids
AlphaFoldDB
AF-P54900-F1-model_v4.pdb
Function
Crucial in the assembly; expression; and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
Sequence
MHRDAWLPRPAFSLTGLSLFFSLVPSGRSMEVTVPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECSNCSEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNAEDGAK
PDB Structures
Ligand Binding
Binding Site
56;135
Disease
Location
Brain specific
DOI ID
10.1073/pnas.95.26.15753
RefSeq
NP_037009.1